Combining the data across the two samples showed genome-wide significance (Bonferroni adjusted α-level of 0.05/524k)50,51 for two SNPs, i.e. rs7590720 (p=9.72×10-9) and rs1344694 (p=1.69×10-8). These SNPs map to the 3′-flanking region of the gene encoding peroxisomal trans-2-enoyl-coA reductase (PECR), located on chromosome 2q35. They are in linkage disequilibrium with each other and with another SNP, rs705648 (p=1.78×10-6),located within the PECR gene (rs1344694 – rs7590720: D′=1.0, r2=0.739; rs1344694 - rs705648: D'= 0.943, r2=0.568; rs7590720 – rs705648: D′=0.948, r2=0.776; HapMap).
