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Chunk #1 — 1. INTRODUCTION — 1.2 Specific measures of alcohol consumption in pregnancy

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Maternal alcohol consumption producing fetal alcohol spectrum disorders (FASD): quantity, frequency, and timing of drinking.
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The search for specific measures of prenatal alcohol use levels and patterns that produce fetal alcohol syndrome (FAS) and other diagnoses within the FASD continuum has been carried out in clinic settings (Alvik et al., 2006a, 2006b, 2006c; Day et al., 1999), drinking surveys (Floyd et al., 1999), epidemiologic studies of various methods (Kvigne et al., 2003; May et al., 2005, 2008a; Petković and Barišić, 2010), and drawn from data in existing populations studies. Few large case control samples exist with mothers who drank heavily during pregnancy giving birth to large numbers of children with an FASD. Such samples provide an opportunity to identify specific alcohol use measures and link them with specific diagnoses in the FASD continuum (Alvik et al., 2006c; Colvin et al., 2007; Kristjanson et al., 2007; May et al., 2009).