Information about the data sources, estimation methods, computational tools, and statistical analysis used in the derivation of our estimates are provided in appendix 1 (p 10). The analytical steps for estimation of burden attributable to single or clusters of risk-outcome pairs are summarised in appendix 1 (p 10). Table 2 provides definitions of exposure for each risk factor, the theoretical minimum risk exposure level (TMREL) used, and metrics of data availability. For each risk, we estimated effect size as a function of age and sex and exposure level, mean exposure, the distribution of exposure across individuals, and the TMREL. The approach taken is largely similar to GBD 2015 for each quantity for each risk. Some methodological improvements have been implemented and new data sources incorporated. Appendix 1 (p 34) provides details of each step by risk. Citation information for the data sources used for relative risks are provided in searchable form through an online source tool.Table 2GBD 2016 risk factor hierarchy and accompanying exposure definitions, theoretical minimum risk exposure level, and data representativeness index for each risk factor, pre-2006, 2006–16,
