To evaluate the magnitude of the effect size for continuous risks, we evaluated the relative risk comparing the 75th percentile with the 25th percentile of the exposure distribution at the global level. RCT=randomised controlled trial. RR=relative risk.*Prospective cohort studies or non-randomised interventions.†Case-control studies were included for those risk-outcome pairs where the sum of RCT and prospective observational studies included was less than five (where applicable).‡Whether or not any biological or mechanistic pathway exists that could potentially explain the relationship of the risk-outcome pair.§Whether or not the risk is associated with another outcome from the same category and whether or not any evidence exists that it can cause the current outcome through the same pathway.
