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Chunk #18 — RESULTS — Effects of ethanol on gene expression

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Ethanol treatment of lymphoblastoid cell lines from alcoholics and non-alcoholics causes many subtle changes in gene expression.
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Ethanol treatment significantly affected the expression of 11,734 probe sets (37% of the expressed probe sets), representing 7,183 unique, named genes, at a stringent Storey FDR ≤ 5% (nominal p-value ≤ 0.039). Most of the expression differences, however, were small (Figure 1).There were 1,393 named genes with absolute fold changes ≥ 1.2, of which 165 had an absolute fold change ≥ 1.4. Twenty-three histone genes were all decreased, more than half with absolute fold changes larger than 1.5 fold. A large number of heat shock proteins were affected by ethanol treatment. A list of differentially expressed genes with fold changes ≥ 1.1 can be found in Supplementary Table 1.