DH is an extraintestinal manifestation of celiac disease, with virtually all patients carrying either HLA-DQ2 or DQ8 haplotypes[26]. There are no known reasons for why DH manifests in some celiac disease cases and not others. It may be that loci at 1q24.3 and 10p11.23 provide a permissive condition for the development of the cutaneous disease, however, it is most probable that the strongest genetic determinants of DH are not celiac disease loci and will require a large, sufficiently powered GWAS of the disease to be discovered.
