Although the HLA genotypes are necessary for celiac disease, they are common and insufficient to cause disease, and each individual celiac patient will have a genetic etiology that includes non-HLA disease alleles. Considerable progress has been made towards elucidating the celiac loci with common disease alleles. This report adds support to previously identified loci, and provides statistical evidence for a celiac disease locus in the FRMD4B gene on 3p14.1, providing the needed confirmation that it is a celiac disease locus. This now brings the total number of identified loci for celiac disease to 41. Furthermore, we found preliminary, suggestive associations of MC and DH with celiac-associated loci at chromosomes 3p21.31, 6q15, 6q25.3,1q24.3, and 10p11.23. Further studies are needed to validate these findings.
