As in our previous study of schizophrenia based on a small number of brain regions 12, we found the strongest signals for telencephalon projecting neurons (i.e. excitatory neurons from the cortex, hippocampus and amygdala), telencephalon projecting inhibitory neurons (i.e. medium spiny neurons from the striatum) and telencephalon inhibitory neurons (Figure 2A and Table S3). We also found that other types of neurons were associated with schizophrenia albeit less significantly (e.g., dentate gyrus granule neurons or hindbrain neurons). Other psychiatric and cognitive traits had similar cellular association patterns to schizophrenia (Figures S5–6 and Table S3). We did not observe any significant associations with immune or vascular cells for any psychiatric disorder or cognitive traits.
