The Partners HealthCare system case-control cohort was assembled using 718 individuals with severely obese individuals of European ancestry who underwent Roux-en-Y gastric bypass surgery in the Partners HealthCare System (Hatoum et al., 2013). 5,822 controls were derived from a population of European participants of the Partners HealthCare Biobank (Karlson et al., 2016). Control participants were excluded if they had undergone bariatric surgery or had a Charlson comorbidity index >3 (Charlson et al., 1987). Samples were imputed to the Haplotype Reference Consortium panel version 1.1 using the Michigan Imputation Server (Das et al., 2016; McCarthy et al., 2016).
