6.72E-33), and ADH1C (SFE = 167.3, SHet = 8.9, p = 1.9E-39). Rs10516440 is a LD proxy (r2 > 0.9) of rs6827898 (Table 2) in populations of European and African descent. These variants are both located in an intergenic region in the ADH gene cluster between ADH1C and ADH7. In line with the fact that the protective coding alleles are associated with increased activity of the enzyme encoded by ADH1B, the major allele rs10516440*A was associated with increased ADH1B expression and reduced AD risk.
