In terms of subjective response, alcohol produced markedly different effects in the 10-year AUD+ and AUD− groups. These differences were evident starting at initial testing and increased further over the course of the re-examination phases (Figure 3). Overall, the AUD+ exhibited increasing sensitivity for pleasurable alcohol responses over the decade of participation, while AUD− showed low initial levels on these measures with little to no change through testing phases. Specifically, alcohol produced initially higher stimulation in AUD+ (vs. AUD−) during the early portion of the BrAC curve that increased in intensity through the re-examination phases [group x time x phase, p=0.016; Table 2]. Alcohol also initially increased ratings of motivational salience (wanting) in 10-year AUD+ relative to AUD− across the entire BrAC curve, and wanting also increased in intensity through the re-examination phases [group x phase, p=0.001]. Initial hedonic reward (liking) from alcohol was also higher in the AUD+ [group, p=0.017] and this effect increased through re-examination, but the escalation was not statistically significant [group x phase, p=0.104]. Finally, both groups showed increases in alcohol-induced sedation, but this effect did
