LDSC (8, 23) was used to calculate hSNP2, partitioned heritability, and rg between anorexia nervosa and other psychiatric, medical, and educational phenotypes. Heritability estimates reported here afford comparison of AN to other major psychiatric disorders. We made comparisons to the psychiatric disorders that have been examined with adequately sized GWAS to afford reliable estimates of heritability, including schizophrenia, bipolar disorder, major depressive disorder, autism, and ADHD. The genetic correlation estimates between AN and 159 additional phenotypes (with publically available GWAS summary statistics) further characterize the genetic architecture of AN, by providing the magnitude and direction of shared genetic effects between AN and diverse psychological, medical, metabolic, and educational phenotypes.
