Cannabinoids can induce transient schizophrenia-like positive, negative, and cognitive symptoms, and exacerbate symptoms in schizophrenic patients. Schizophrenic patients and others who are psychosis-prone may be more likely to experience transient positive, negative, and cognitive symptoms following exposure to cannabinoids, and these effects may be greater in magnitude and duration relative to healthy individuals. The effects of cannabinoids on increasing DA, reducing GABA, and reducing glutamatergic neurotransmission may contribute to their capacity to induce transient positive, negative, and cognitive symptoms, but the precise mechanism remains unclear.
