The effects of an allele even as strong as ADH1B*2 can be modulated by the environment: the delayed age of first intoxication and first DSM5 symptom in adolescents was reduced if most of their friends drink (Olfson et al., 2014). ADH1B*2 has a stronger effect on alcohol consumption and risk for AUD among those who experience childhood adversity (Meyers et al., 2015).
