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Chunk #24 — Alcohol dehydrogenases — ADH1B*3

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Alcohol Dehydrogenases, Aldehyde Dehydrogenases, and Alcohol Use Disorders: A Critical Review.
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ADH1B*3 is found almost exclusively in individuals of African origin (Table 2). Individuals with an ADH1B*3 allele (ADH1B*369Cys; rs2066702) metabolize ethanol somewhat faster than those with only ADH1B*1 alleles (Thomasson et al., 1995). Within Africa and in African Americans, allele frequencies for ADH1B*3 range from 0.09 to 0.28; in other populations it is essentially absent (Table 2). There are many fewer studies of African populations, an omission that needs to be corrected.