To date, higher SRE-5 and SRE-T scores have been found in both cross-sectional and longitudinal studies to relate to heavy drinking and alcohol problems (e.g. Daeppan et al., 2000; Pedersen & McCarthy, 2009; Ray & Hutchison, 2009; Schuckit & Smith, 2013; Schuckit et al., 2019a,b). A few studies have reported data regarding how alcohol use correlates with SRE-3 and/or SRE-H (e.g., Ray & Hutchison, 2009; Schuckit & Smith, 2017). Ray and Hutchison (2009) studied 124 hazardous drinkers and reported significant correlations of SRE-3 to maximum drinks and alcohol problems of 0.54 and 0.19, respectively, along with SRE-H correlations of 0.72 and 0.32, respectively. Schuckit and Smith’s (2017) prospective study of 390 men recorded a significant 0.33 correlation between age 36 SRE-3 values and age 51 alcohol problems. However, no other study known to the authors has compared the cross-sectional and prospective performance of the four potential SRE scores and alcohol challenge results across the sexes and different age groups while controlling for ethnicity.