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Chunk #45 — Online Methods — Statistical methods — Statistical criteria for replication

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Genome-wide association analysis identifies novel blood pressure loci and offers biological insights into cardiovascular risk.
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For the GWAS discovery, there are ˜9.8 million SNVs with MAF ≥ 1% and INFO > 0.1. We consider for follow-up any SNVs with P < 1x10-6 for any of the three BP traits. For the exome discovery, there are 149,026 exome SNVs (Supplementary Note) which were polymorphic with INFO > 0.1; for follow-up we consider all SNVs with MAF ≥ 0.01% and P < 1x10-5. All such SNVs are annotated to loci according to both an LD threshold of r2 ≥ 0.2 and a 1Mb interval region (see Supplementary Note), and signals are classified either as belonging to unvalidated loci, or being potential secondary signals at previously reported loci at the time of analysis.