The sentinel (most significant) SNV from each association signal is selected for follow-up, all of which are pairwise-independent by LD (r2 < 0.2). For the GWAS discovery, we check that potential lookup SNVs are covered within the ICBP-1000G replication data (Supplementary Note; Supplementary Tables 28 and 29). Of the 235 novel loci containing previously unreported SNVs with MAF ≥ 1%, INFO > 0.1 and P<1x10-6, 218 are covered, and similarly 100 of the 123 potential secondary SNVs at 51 of the 54 previously reported BP loci are available for follow-up. For the exome discovery, by following up SNVs with MAF ≥ 0.01%, INFO > 0.1 and P < 1x10-5 across the three BP traits, we carry forward for replication sentinel SNVs at 22 unvalidated loci, and potential secondary SNVs at three previously reported loci at the time of analysis. We produce locus zoom plots for each of the lookup variants.
