while showing hypoconnectivity across long-range interhemispheric and anterior-posterior connections. Although frontal hypoconnectivity in EEG and hyperconnectivity in fMRI as manifested by AUD are seemingly contradictory, it is quite possible in the context of biophysical basis of the two modalities with regard to excitation and inhibition [144,145]. Recent fMRI studies have reported restricted PCC connectivity with right medial frontal gyrus during resting state [26] as well as cue-elicited prefrontal hypoactivation in abstinent AUD individuals [146]. These findings suggest that hypoconnectivity of the prefrontal sub-network may indicate a fractured prefrontal network and associated dysfunction in executive functioning and reward/affective processing in AUD individuals [20,147].
