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Chunk #52 — 4. Discussion — 4.2. Poor Neuropsychological Performance in AUD

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Random Forest Classification of Alcohol Use Disorder Using EEG Source Functional Connectivity, Neuropsychological Functioning, and Impulsivity Measures.
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The RF classifier identified three scores of memory performance in VST (i.e., total number of correctly performed trials in forward and backward sequences, and average time of correct trials in forward sequence) as important to classify AUD from CTL individuals. In other words, the AUD participants showed poor performance in visual memory capacity (forward span), visual working memory (backward span) and slower memory performance (average time taken during encoding and/or retrieval) compared to CTL participants. While the forward recall mainly involves passive storage of the items, backward recall additionally involves attentional demand [148]. The backward condition of the VST taps both immediate visual memory and components of visuospatial working memory [149]. Therefore, lower scores in forward and backward span in AUD group indicate deficits in memory storage capacity as well as visual working memory, which are possibly resulting from chronic drinking in AUD individuals [11]. Interestingly, poor memory performance (low score on forward memory span) was associated with hyperconnectivity in three delta and alpha band connections, where AUD group showed both hyperconnectivity and poor memory performance. On the other hand,