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Chunk #20 — Results — Study of FKBP5 Genotype in Humans

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Evidence for a Link Between Fkbp5/FKBP5, Early Life Social Relations and Alcohol Drinking in Young Adult Rats and Humans.
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The mean age of the 838 young male adults was 22.1 ± 1.4 (20–24) years for which FKBP5 rs1360780 genotype data were available (HWE χ 2 = 0.66, p = 0.42), and the age at first intoxication was 15.7 ± 1.9 years. The majority reported to drink 2 to 4 times a month, and consumed on average 5–6 drinks containing alcohol in a typical occasion, with AUDIT scores of 7.6 ± 5.2 (0–29). They reported that their relationship with their parents until the age of 18 years was 4.3 ± 1.5 on a scale between 0 and 6. Only 3.9 % never lived with both biological parents from birth to the age of 18, whereas 60.7 % always lived with both biological parents. Though the FKBP5 rs1360780 TT genotype group associated with higher AUDIT scores, FKBP5 rs1360780 genotype frequencies (CC: 53.2 %, TC: 40.2 %, TT: 6.6 %) did not differ regarding alcohol intake or relationship with the parents (Table S4). No correlation was observed between AUDIT and parent-child relationship, except among TT carriers for whom problematic drinking was associated