AUD is unclear and is attributed to reduced connectivity or increased connectivity (17–21). None of the studies has explored the association between anatomical aberration (volume changes) and FC dysfunction in these networks (17–21). These issues warrant the need for comprehensively and simultaneously examining the degree of FC in the key nodes of these networks and the interaction between them that may contribute to the neurobiology of AUD. To address these issues, we used rs-fMRI in combination with voxel-based morphometry (VBM) to examine the three networks implicated in the pathophysiology of AUD.
