previous study9, we utilized data on International Classification of Diseases (ICD)-diagnosed AUD (Ncase = 136,182 and Ncontrol = 692,594), DSM-IV AD (Ncase = 29,770 and Ncontrol = 70,282) and AUDIT–P (N = 151,119), together defined as PAU (based on high genetic correlations (rg > 0.7) across these measures). The total number of AUD and AD cases was 165,952, almost double the 85,391 cases in the previously largest study27.Table 1Demographics for cohorts in the meta-analysis of PAUCohortsTraitsNcaseNcontrolNtotalNfemale (%)NeffectiveRef. aEUR ancestryMVPAUD80,028368,113448,14133,345 (7.4)262,9479 and newFinnGenAUD8,866209,926218,792123,579 (56.5)34,027NewbUKB–EUR1AUDIT–P––132,00174,113 (56.1)132,0019 and newUKB–EUR2AUDIT–P––17,89810,529 (58.5)17,898NewPGCAD9,93830,99240,93020,933 (51.1)23,0758dQIMR AGDSAD6,7264,46711,1938,605 (76.9)10,737NewQIMR TWINSAD2,7725,6308,4024,922 (58.6)7,4308 and newQIMR GBPAD1,2877512,0381,435 (70.4)1,897NewiPSYCH1AD2,11713,23815,3558,077 (52.6)7,301NewiPSYCH2AD1,0245,7326,7563,607 (53.4)3,475NewYP3AD5671,0741,641854 (52.0)1,484NewSubtotalPAU113,325639,923903,147289,999 (32.1)502,272AFR ancestryMVPAUD36,33079,100115,43016,084 (13.9)99,58310 and newPGCAD3,3352,9456,2803,124 (49.7)4,9918YP3AD451410861430 (50.0)959NewSubtotalAUD40,11682,455122,57119,638 (16.0)105,433LAMVPAUD10,15028,81238,9623,731 (9.6)30,02310 and newEASa ancestryMVPAUD7016,2546,955747 (10.7)2,52126Han Chinese–GSAAD5332,8483,3811,012 (29.9)1,796Thai METH–MEGAAD7941,5762,3701,008 (42.5)2,112Thai METH–GSAAD127405532263 (49.4)387Han Chinese–CytoAD992143130 (0)271SubtotalAUD2,25411,29713,5513,030 (22.4)7,087SAS ancestryMVPAUD10738949667 (13.5)33610 and newUKB–SASAUDIT–P––1,220535 (43.9)1,220NewSubtotalPAU1073891,716602 (35.1)1,556TotalPAU165,952762,8761,079,947317,000 (29.4)646,371Note:aData either published in previous alcohol GWAS or newly included for this project.bFinnGen summary statistics were downloaded from FinnGen data freeze v5 (https://r5.finngen.fi/).cIncluded related individuals from UKB.dReran the PGC AD GWAS in EUR excluding two Australian cohorts.Cohorts are described in the Methods. UKB–EUR1: genetically defined EUR ancestry White-British by UKB; UKB–EUR2: genetically defined EUR non-White-British participants (Methods); AGDS, the Australian Genetics of Depression Study; TWINS, the Australian twin family study of AUD; GBP,
