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Chunk #19 — 2. Materials and Methods — 2.9. Statistical Analysis

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Plasticity associated with escalated operant ethanol self-administration during acute withdrawal in ethanol-dependent rats requires intact matrix metalloproteinase systems.
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Data from the acute FN-439 control condition was analyzed using a paired-sample t-test to compare the escalated and FN-439 sessions. The data from the second control condition consisting of aCSF infusions for those animals originally receiving acute FN-439 treatments was analyzed using a one-way repeated measure ANOVA with session as the within-subjects factor and followed by post-hoc Least Significant Difference (LSD) tests to compare ethanol intake (g/kg) over the three aCSF-treated sessions.