As a result of the histological verification of cannula placement, two animals in the chronic aCSF treatment group were removed from the study. Additionally, three animals (one in the acute FN-439 and two from the acute aCSF group) removed their cannula guides during the one-month dependence induction phase and were eliminated from the study. Therefore, of the 38 animals that began the study, 33 were included in the data analysis.
