Chunk #23 — Results — Genome-wide association analysis, biological annotation, gene, and transcriptome-based association analyses

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Genome-wide association study of problematic opioid prescription use in 132,113 23andMe research participants of European ancestry.

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For the second genome-wide significant SNP (rs640561), a phenome-wide scan in UKB revealed nominal associations (p > 7.00E-03) with neurological, metabolic and other psychiatric traits, such as ADHD (Supplementary Table 4). LRRIQ3, which is the nearest gene, has previously been associated with lifetime smoking [27].