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Chunk #23 — 3. RESULTS — 3.2 MRI Outcome Measures — ICV-normalized subcortical volumes

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Structural brain differences in alcohol-dependent individuals with and without comorbid substance dependence.
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MANOVA revealed a significant main effect of group for subcortical tissues [F(2, 80) = 2.65, p = 0.005]. Significant group effects were observed for thalamic GM [F(2, 80) = 5.95, p = 0.004] and total cerebellar volume [F(2, 80) = 3.25, p = 0.044]. Pairwise comparisons showed PSU had smaller lenticular and thalamic GM volumes than LD, and ALC had smaller thalamic GM and total cerebellar volumes than LD. ALC and PSU had statistically similar volumes of all the subcortical regions examined.