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Chunk #222 — VIII. A possible underlying neurobiology: connectivity constellations

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Molecular genetics of addiction and related heritable phenotypes: genome-wide association approaches identify "connectivity constellation" and drug target genes with pleiotropic effects.
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We can seek overlap between these “bioinformatic search cell adhesion molecule genes” and the 99 genes that we have 1) identified by clustered, nominally-positive SNPs in one or more of the genome wide association studies described above and 2) independently (GRU) annotated as “cell adhesion related”. Sixty-four of the 99 genes that we identified as “cell adhesion related” in genome wide association datasets are included on this independently-derived list of “bioinformatic search cell adhesion molecules”. These 64 overlapping genes represent 12.9% of all of the “bioinformatic search cell adhesion molecule genes” that we can identify in the genome. These 64 genes total 35,619,485 bp, representing 1.2% of the genome and 2.8% of currently annotated gene sequences.