Chunk #221 — VIII. A possible underlying neurobiology: connectivity constellations

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Molecular genetics of addiction and related heritable phenotypes: genome-wide association approaches identify "connectivity constellation" and drug target genes with pleiotropic effects.

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With this set of genes in hand, we were now able to estimate the fraction of the genome that they represent. These 496 genes represent 1.6% of the 31,227 human genes now annotated by RefSeq. These 496 genes are often large, occupying a total of 73,695,264 bp of the genome. These sequences thus represent 2.4% of the 3,080,436,051 bp currently-elucidated human genome sequence. These genes represent 5.8% of the 1,271,259,295 bp currently annotated as gene sequences (eg exon, intron and 10kb 3’ and 5’ flanking sequence).