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Chunk #17 — DISCUSSION

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Role of GABRA2 in moderating subjective responses to alcohol.
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This is the first association study of GABRA2 polymorphisms with subjective responses to alcohol using the objective method of intravenous alcohol administration, i.e., the alcohol clamp. The most consistent finding in this study was an effect of GABRA2 SNPs 4 to 6 (rs279869, rs279858, and rs279837) on subjective responses to alcohol in nondependent drinkers.