In the present study, subjects with 1 or more C allele at SNP4 (A allele at SNP5) and with ALDH2*1/*2 reported greater initial responses to alcohol (as measured on the SS) compared with subjects who were homozygous for the A allele at SNP4 (G allele at SNP5). In subjects with ALDH2*1 /*1, however, there was no significant effect of the genotype of SNPs 4 and 5 on the initial response with the exception that SNP4 C-allele (SNP5 A-allele) carriers showed a trend for higher scores in Stimulant subscale of the BAES than SNP4 A-allele (SNP5 G-allele) homozygotes. On the other hand, subjects with the T allele at SNP6 presented greater subjective responses to alcohol than did individuals homozygous for the C allele, without regard to ALDH2 genotype. The results for initial responses might be interpreted in the context that the role of GABRA2 in the subjective responses to alcohol could be independent of ALDH2. As for the acute adaptation, only participants with ALDH2*1/*1 reported significantly different subjective effects of alcohol according to the genotype of GABRA2 SNP6. These results for
