GO annotation of the SH DW genes revealed a significant enrichment (FDR < 4 × 10−12) in genes (N = 137) associated with the synaptic component (Supplementary Table S8); genes in this category and not noted previously included Adam10, Arrb1, Epha4, Grm4&7, Homer1, P2ry1, Snap25&29, Synpo, and Synpr. The SH DW genes were enriched in five network modules, most prominently in the green module (p < 4 × 10−9). The green module was significantly enriched in genes associated with the synaptic component (p < 2 × 10−8), nervous system development (p < 1 × 10−4) and enzyme binding (p < 2 × 10−2). For nine modules, the number of DW genes was significantly less than expected. For the green module DW genes, intramodular connectivity on average showed no change between the Low and High lines (0.61 vs. 0.62, respectively).
