GO annotation of the PL DW genes revealed a significant enrichment in genes (N = 75) associated with the synaptic component (FDR < 2 × 10−8) and in genes (N = 282) associated with development (FDR < 2 × 10−4; Supplementary Table S8). Genes in the synapse category and not noted previously included Cadm1&2, Dmd, Kcna2&4, Phactr1, Snph, Sntb1, and Tln1. The PL DW genes were significantly enriched in two network modules, brown and green. The brown module is described above. The green module was enriched in genes associated with regulation of cellular localization (FDR < 2 × 10−2) and in genes associated with the neuronal component (FDR < 6 × 10−4). Different from the CeA and SH, only one PL module (yellow) showed significant conservation (corrected p < 0.05). For the brown module DW genes, relative intramodular connectivity increased in the High vs. Low line (0.59 vs. 0.24; p < 6 × 10−56). Genes moving from non-hub status (Low line) to hub status (High line) included Sox6, Egr3, Soga3, Pcdhgb5, Pcdhga8, Senp5, and Prkg1. For the green module DW
