Chunk #40 — Results — RYR3: Regulation of initial sensitivity to ethanol in C. elegans, rapid tolerance to ethanol in Drosophila, and motivation to self administer alcohol in rats

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Genomewide Association Study of Alcohol Dependence Identifies Risk Loci Altering Ethanol-Response Behaviors in Model Organisms.

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C. elegans has one RyR gene, unc-68. We tested the effect of ethanol on two strains carrying different unc-68 mutations (r1161 and r1162). Loss of unc-68 confers reduced sensitivity to ethanol (minimum p<0.001 for r1162, Figure 4E, F). We also observed consistent effects of mutations in two additional genes with products involved in calcium regulation and known to interact with UNC-68 (Supplementary Materials and Methods, Supplementary Results and Supplementary Figure S7).