Chunk #39 — Results — RYR3: Regulation of initial sensitivity to ethanol in C. elegans, rapid tolerance to ethanol in Drosophila, and motivation to self administer alcohol in rats
Previous studies have implicated ryanodine receptors (RyR) in ethanol phenotypes: in humans, RYR3 was implicated in a GWAS of alcohol response (Joslyn et al., 2010). Ryr1 and Ryr2 upregulation in mouse brain is observed following acute exposure to multiple drugs including alcohol (Kurokawa et al., 2010; Kurokawa et al., 2013) and behavioral changes like conditioned place preference and withdrawal expected following acute exposure are blocked by the RyR antagonist dantrolene (Kurokawa et al., 2010; Kurokawa et al., 2013).
