Chunk #41 — Results — RYR3: Regulation of initial sensitivity to ethanol in C. elegans, rapid tolerance to ethanol in Drosophila, and motivation to self administer alcohol in rats

Source

Genomewide Association Study of Alcohol Dependence Identifies Risk Loci Altering Ethanol-Response Behaviors in Model Organisms.

Embedded

yes

Text

There is a single RYR3 ortholog in Drosophila, RyR. We found that two insertional mutations that cause partial loss of function in RyR reduce the development of rapid tolerance to ethanol with no obvious effects on initial sensitivity (Supplementary Materials and Methods, Supplementary Results and Supplementary Figure S8).