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Chunk #1 — Introduction

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Alcohol use disorder is associated with altered frontomedial phase-amplitude coupling strength during resting state.
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be a general feature of substance use disorders (Woisard et al., 2021). Numerous investigations into the relationship between AUD on EEG coherence, have reported significantly greater coherence in the theta frequency band compared to non-alcoholic controls indicating aberrant hyper-connectivity between brain hemispheres (De Bruin et al., 2004; Kim et al., 2020; Meyers et al., 2021; Porjesz and Rangaswamy, 2007). The relationship between these patterns of hyper- and hypo-connectivity and AUD symptomatology remains unclear.