Chunk #46 — Online Methods — Genome-wide survival association study datasets — (4) Cohorts for Heart and Aging Research in Genomic Epidemiology (CHARGE)
Persons suspected to have cognitive impairment based on the screening tests listed above underwent a neuropsychological and a neurological evaluation. The neuropsychological battery included the following tests: the American version of the National Reading test (AMNART), Raven’s Coloured Progressive Matrices, California Verbal Learning Test (CVLT), a modified Rey-Osterreith figure, the Boston Naming test, the Verbal fluency test, the Block design test, the Trails A and B tests, the Baddeley & Papagno Divided Attention Task, the Stroop, Digit Span and Grooved Pegboard Tests. The results of the neuropsychological battery were classified as normal or abnormal (>1.5 standard deviations below individuals of comparable age and education) based on normative data collected from a sample of 250 unimpaired subjects. The neurological exam included a brief mental status examination, as well as a complete examination of other systems. The examiner also completed the Unified Parkinson’s Disease Rating Scale (UPDRS) and the Hachinski Ischemic Scale. After completing the neurological exam, the neurologist classified the participant as normal, having mild cognitive impairment (MCI), or dementia.
