Chunk #45 — Online Methods — Genome-wide survival association study datasets — (4) Cohorts for Heart and Aging Research in Genomic Epidemiology (CHARGE)
Beginning in 1988/89, all participants completed the Modified Mini-Mental State Examination (3MSE) and the DSST at their annual visits, and the Benton Visual Retention Test (BVRT) from 1994 to 1998. The Telephone Interview for Cognitive Status (TICS) was used when participants did not come to the clinic. Further information on cognition was obtained from proxies using the Informant Questionnaire for Cognitive Decline in the Elderly (IQCODE), and the dementia questionnaire (DQ). Symptoms of depression were measured with the modified version of the Center for Epidemiology Studies Depression Scale (CES-D). In 1991–94, 3,608 participants had an MRI of the brain and this was repeated in 1997–98. The CHS staff also obtained information from participants and next-of-kin regarding vision and hearing, the circumstances of the illness, history of dementia, functional status, pharmaceutical drug use, and alcohol consumption. Data on instrumental activities of daily living (IADL), and activities of daily living (ADL) were also collected.
