Preliminary OPRM1 genotype differences were observed at the Z>2.3 threshold with alcoholism severity included as a covariate. Specifically, G-allele carriers were found to exhibit greater pre- versus post-priming alcohol cue-reactivity activation in regions including the left caudate, thalamus, putamen, and bilateral supramarginal gyrus and parietal operculum cortex, as compared to the A-allele homozygotes (Table 5).
