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Chunk #18 — RESULTS — Opioid Dependence vs. Exposed and Unexposed Controls

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Leveraging genome-wide data to investigate differences between opioid use vs. opioid dependence in 41,176 individuals from the Psychiatric Genomics Consortium.
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Additionally, in the African-ancestry meta-analysis, we also observed an enrichment for adipose tissue (beta=0.04, p=4.21×10–4; Figure 2A) and GO:0034498 – early endosome to Golgi transport (beta=1.01, p=5.1×10–8). In the trans-ancestry meta-analysis, we observed significant enrichment for specific adult stages of brain development (37 y; beta=0.06, p=6.22×10–4; 15 y; beta=0.06, p=0.001; 36yrs: beta=0.06, p=0.002; Figure 2B) and GO:0007143~female meiotic division (beta=0.73, p=1.08×10–7). In the European-ancestry ODunexposed GWAS meta-analysis, no result survived multiple testing correction.