To extend the phenotypic breadth of our findings, we conducted a phenome-wide scan (4,082 traits tested; Supplementary Table 7) identified in 361,194 participants of European descent from the UK Biobank. Rs201123820 was identified in the African-ancestry ODunexposed GWAS meta-analysis. Although this variant was not significant in the European-ancestry meta-analysis (Supplementary Table 5), Rs201123820 has reasonably similar MAF in African and European populations (1000 Genomes Project: AFR MAF=0.024; EUR MAF=0.042). In UK Biobank cohort, we observed several associations for rs201123820 (FDR q<0.05; Figure 3, center panel; Supplementary Table 7) including postprocedural musculoskeletal disorders (UK Biobank Field ID: 41202 “Diagnoses – main ICD10 [M96]”, p=4.88×10−7), other disorders of the musculoskeletal system and connective tissue (UK Biobank Field ID: 41270 “Diagnoses - ICD10 [M13_MUSCULOSKELEOTH]”, p=1.25×10−5), postpartum care and examination (UK Biobank Field ID: 41202 “Diagnoses - main ICD10 [Z39]”, p=3.74×10−5), and auto-refraction measurements for eye prescription (UK Biobank Field ID: 5159 “3mm asymmetry index (right)”, p=6.54×10−5).
