Importantly, canSAR also provides a comprehensive and weekly updated structure-based ligandability assessment. canSAR contains ligandability assessment for >4.5 million cavities of which >180 000 are predicted to be ligandable using our predictor. We also analysed >651 000 cavities on >126 000 protein–protein interfaces and identified >81 000 ligandable protein-protein interfaces. New enhancements to canSAR’s evaluation of ligandable sites enable the identification of secondary, regulatory and allosteric ligandable sites. canSAR identified >10 000 non-primary ligandable sites.
