of this group are found in the core module grouping. Within the core module grouping, we identified the 18 genes that were hub nodes across all three regions; we next aligned these genes with the 25 common DV genes found in the core module. Our rationale for this step was to identify high priority hub nodes, that could be targeted in future studies. Six genes were identified: Dlg2, Gatad2b, Pcdhac2, Tnks, Usp29, and Usp9x. Dlg2 encodes for post-synaptic density protein 93 (PSD-93), Gatad2b encodes for transcriptional repressor p66-beta, Pcdhac2 encodes for protocadherin αc2, Tnks encodes for Tankyrase-1, Usp29 encodes for ubiquitin specific protease 29 and Usp9x encodes for ubiquitin specific protease 9, X-linked. That two ubiquitin-related genes are in this group cannot be unexpected, given the long standing observations that ubiquitination is associated with chronic ethanol exposure in both animals and humans (see Sokolov et al., 2003; Liu et al., 2006; Contet, 2012; Melendez et al., 2012; Widagdo et al., 2017). Our data link ubiquitination to risk for excessive consumption. The precise mechanisms are unknown but we note here that ubiquitination has a key role in glutamate receptor trafficking (Widagdo et al., 2017). The functions of Tankyrase-1 (Tank-1) in the
