Other substances of abuse have only been tangentially linked to microglial dysfunction. Striatal microglia are activated by psychostimulants, and a temporal correlation exists between microglial activation and methamphetamine-induced neurotoxicity/tolerance (Thomas et al. 2004a,b). Microglia also mediate some of methamphetamine’s behavioral effects; for instance, minocycline attenuates striatal methamphetamine-induced neurotoxicity and reduces hyperlocomotion (Zhang et al. 2006).
