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Chunk #17 — Materials and Methods — Genotyping and Ancestry Informative markers (AIM)

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Independent and Interactive Effects of OPRM1 and DAT1 Polymorphisms on Alcohol Consumption and Subjective Responses in Social Drinkers.
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and assumed a model with the possibility of admixture and correlated allele frequencies between populations; all other parameters were kept at their default values. In order to increase the accuracy of inferred genetic ancestry, the AIMs were used to generate component coordinates (C1 and C2) using a large data set (n=546), which included participants for the current study as well as other research participants who completed genotyping procedures for other studies conducted in our laboratory. Individual C1 and C2 coordinates were included in our statistical models as covariates.