We found significant genetic correlations between BD and other psychiatric-relevant traits (Supplementary Table 10B), including autism spectrum disorder 8 (rg = 0.18, P=2×10−4), anorexia nervosa 36 (rg = 0.23, P=9×10−8), and subjective well-being 34 (rg = −0.22, P=4×10−7). There was suggestive positive overlap with anxiety disorders (rg=0.21, P=0.04) 37 and neuroticism (rg=0.12, P=0.002) 38. Significant rgs were seen with measures of education: college attendance 39 (rg = 0.21, P=1=x10−7) and education years 40 (rg=0.20, P=6×10−14), but not with childhood IQ 41 (rg=0.05, P=0.5) or intelligence 42 (rg=−0.05, P=0.08). Among a large number of variants in BD risk loci that were associated with additional traits in the GWAS catalog 43, we found a handful of loci with non-independent associations (in one overlapping locus with each of educational attainment, biliary atresia, bone mineral density, lipid-related biomarkers) (Supplementary Table 9). Biliary atresia and lipid- related biomarkers, however, did not show significant genetic correlation with BD (Supplementary Table 10B).
