We next examined the genetic relationships of BD to other psychiatric disorders and traits. Of the 30 genome-wide significant BD loci, 8 also harbor schizophrenia (SCZ) associations 31,32. Based on conditional analyses, the BD and SCZ associations appear to be independent at 3 of the 8 shared loci (NCAN, TRANK1 and chr7q22.3:105Mb) (Supplementary Table 9). No genome-wide significant BD locus overlapped with those identified for depression (DEPR), including 44 risk loci identified in the most recent PGC GWAS of major depression 33, and those reported in a large study of depressive symptoms or subjective well-being 34. As previously reported 35, we found substantial and highly significant genetic correlations between BD and SCZ 31 (LD-score regression estimated genetic correlation rg = 0.70, se = 0.020) and between BD and DEPR 33 (rg = 0.35, se = 0.026). The BD and DEPR genetic correlation was similar to that observed for SCZ and DEPR (rg = 0.34, se = 0.025) (Supplementary Table 10A).
