To identify additional independent signals, we conducted conditional analyses across each of the 30 significant BD loci (Supplementary Table 8). We used the effective number of independent variants based on LD structure within loci 30 to calculate a multiple test-corrected significance threshold (p=1.01×10−5, see Supplementary Note). Only one locus showed evidence for an independent association signal (rs114534140 in locus #8, FSTL5; pconditional = 2×10−6). At another locus (#30,STK4 on chr 20), we found two SNPs with genome-wide significance in low LD (R2 < 0.1); however, conditional analysis showed that their associations were not independent.
