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Chunk #32 — Discussion

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The impact of focusing a program to prevent heavier drinking on a pre-existing phenotype, the low level of response to alcohol.
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The impact of ethnicity is important to recognize. This variable was emphasized because higher LRs are seen in Asians and AA individuals and lower values in EA and Hispanic subgroups (Ehlers et al., 2004; Eng et al., 2007; Pederson et al., 2013; Schuckit et al., 2012b), and rates of heavy drinking and alcohol problems are higher in EA and Hispanic groups and lower in Asians and AAs (Barnett et al., 2014; Eng et al., 2007; Li et al., 2011). The role of race/ethnicity in the current work was supported by interactions for maximum and usual quantities, and the significant ethnicity main effects for all four outcomes in Tables 3 and 4. Additional support comes from the result that when the variance explained by ethnicity was allowed to remain in the error term in the evaluations of 3-way interactions in ANOVAs using sex instead of ethnicity, the 3-way interaction became non-significant. Space constraints do not allow for more extensive evaluation of which ethnic groups contributed most to the results and the mechanisms associated with those effects, but we will return to those questions in future reports.